Human Syntenin-1, SDCBP ELISA Kit

SKU: E4148hu

Size:96 Tests-1 Kit

Background:Multifunctional adapter protein involved in diverse array of functions including trafficking of transmembrane proteins, neuro and immunomodulation, exosome biogenesis, and tumorigenesis (PubMed: 26291527). Positively regulates TGFB1-mediated SMAD2/3 activation and TGFB1-induced epithelial-to-mesenchymal transition (EMT) and cell migration in various cell types. May increase TGFB1 signaling by enhancing cell-surface expression of TGFR1 by preventing the interaction between TGFR1 and CAV1 and subsequent CAV1-dependent internalization and degradation of TGFR1 (PubMed: 25893292). In concert with SDC1/4 and PDCD6IP, regulates exosome biogenesis (PubMed: 22660413). Regulates migration, growth, proliferation, and cell cycle progression in a variety of cancer types (PubMed: 26539120). In adherens junctions may function to couple syndecans to cytoskeletal proteins or signaling components. Seems to couple transcription factor SOX4 to the IL-5 receptor (IL5RA) (PubMed: 11$498.00|$360.00591). May also play a role in vesicular trafficking (PubMed: 11179419). Seems to be required for the targeting of TGFA to the cell surface in the early secretory pathway (PubMed: 10230395).

Research_area:Others

Applications:ELISA

Target_protein:SDCBP

Reactivity:Human

Assay type:Sandwich

Sensitivity:0.02ng/ml

Detection range:0.05-15ng/ml

Sample type:Serum, plasma or other biological fluids

Full product name:Syntenin-1

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:O00560

MASS(Da):32,444

GeneID:6386

Synonyms:MDA-9;Melanoma differentiation-associated protein 9;Pro-TGF-alpha cytoplasmic domain-interacting protein 18;Scaffold protein Pbp1;SDCBP;Syndecan-binding protein 1;Syntenin-1;TACIP18

Gene names:SDCBP

Standard solution:16ng/ml