Human Syntaxin-1A, STX1A ELISA Kit

SKU: E4672Hu

Size:96 Tests-1 Kit

Background:Plays an essential role in hormone and neurotransmitter calcium-dependent exocytosis and endocytosis (PubMed: 26635000). Part of the SNARE (Soluble NSF Attachment Receptor) complex composed of SNAP25, STX1A and VAMP2 which mediates the fusion of synaptic vesicles with the presynaptic plasma membrane. STX1A and SNAP25 are localized on the plasma membrane while VAMP2 resides in synaptic vesicles. The pairing of the three SNAREs from the N-terminal SNARE motifs to the C-terminal anchors leads to the formation of the SNARE complex, which brings membranes into close proximity and results in final fusion. Participates in the calcium-dependent regulation of acrosomal exocytosis in sperm (PubMed: 23091057). Plays also an important role in the exocytosis of hormones such as insulin or glucagon-like Peptide 1 (GLP-1) (By similarity).

Research_area:Neuroscience

Applications:ELISA

Target_protein:STX1A

Reactivity:Human

Assay type:Sandwich

Sensitivity:5.11ng/L

Detection range:10-2000ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Syntaxin-1A

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q16623

MASS(Da):33,023

GeneID:6804

Synonyms:Neuron-specific antigen HPC-1;STX 1A;STX1A;Syntaxin-1A

Gene names:STX1A

Standard solution:2400ng/L