Human Synaptotagmin 11, SYT11 ELISA Kit

SKU: E2573Hu

Size:96 Tests-1 Kit

Background:Synaptotagmin family member involved in vesicular and membrane trafficking which does not bind Ca2+. Inhibits clathrin-mediated and bulk endocytosis, functions to ensure precision in vesicle retrieval. Plays an important role in dopamine transmission by regulating endocytosis and the vesicle-recycling process. Essential component of a neuronal vesicular trafficking pathway that differs from the synaptic vesicle trafficking pathway but is crucial for development and synaptic plasticity. In macrophages and microglia, inhibits the conventional cytokine secretion, of at least IL6 and TNF, and phagocytosis. In astrocytes, regulates lysosome exocytosis, mechanism required for the repair of injured astrocyte cell membrane (By similarity). Required for the ATP13A2-mediated regulation of the autophagy-lysosome pathway (PubMed:27278822).

Research_area:Neuroscience

Applications:ELISA

Target_protein:SYT11

Reactivity:Human

Assay type:Sandwich

Sensitivity:0.022ng/ml

Detection range:0.05-10ng/ml

Sample type:Serum, plasma or other biological fluids

Full product name:Synaptotagmin 11

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q9BT88

MASS(Da):48,297

GeneID:23208

Synonyms:Synaptotagmin XI;Synaptotagmin-11;SYT11;SYT12;sytXI

Gene names:SYT11

Standard solution:12.8ng/ml