Human Sterol regulatory element-binding protein 2,SREBF2 ELISA KIT

SKU: E7196Hu

Size:96 Tests-1 Kit

Background:[Sterol regulatory element-binding protein 2]: Precursor of the transcription factor form (Processed sterol regulatory element-binding protein 2), which is embedded in the endoplasmic reticulum membrane (PubMed:32322062). Low sterol concentrations promote processing of this form, releasing the transcription factor form that translocates into the nucleus and activates transcription of genes involved in cholesterol biosynthesis (PubMed:32322062). {ECO:0000269|PubMed:32322062}.; [Processed sterol regulatory element-binding protein 2]: Key transcription factor that regulates expression of genes involved in cholesterol biosynthesis (PubMed:12177166, PubMed:32322062). Binds to the sterol regulatory element 1 (SRE-1) (5'-ATCACCCCAC-3'). Has dual sequence specificity binding to both an E-box motif (5'-ATCACGTGA-3') and to SRE-1 (5'-ATCACCCCAC-3') (PubMed:7903453, PubMed:12177166). Regulates transcription of genes related to cholesterol synthesis pathway (PubMed:12177166, PubMed:32322062). {ECO:0000269|PubMed:12177166, ECO:0000269|PubMed:32322062, ECO:0000269|PubMed:7903453}.

Research_area:

Applications:ELISA

Target_protein:SREBF2

Reactivity:Human

Assay type:Sandwich

Sensitivity:4.97ng/L

Detection range:10-2000ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Sterol regulatory element-binding protein 2

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q12772

MASS(Da):123688

GeneID:6721

Synonyms:SREBF2 BHLHD2 SREBP2

Gene names:SREBF2

Standard solution:2400ng/L