Human SPINK1/TATI ELISA Kit PicoKine®

SKU: EK1241

Size: 96 wells/kit, with removable strips.

Storage: Store at 4℃ for 6 months, at -20℃ for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Form:

Reactivity: Human

Applications: ELISA

Application Details:

Gene Name: SPINK1

Specificity: Natural and recombinant human SPINK1

Background: Serine protease inhibitor Kazal-type 1, also called TATI or PSTI, is a protein that in humans is encoded by the SPINK1 gene. It is mapped to 5q32. SPINK1 gene contains 4 exons spanning approximately 7.5 kb. It was initially detected in urine of patients with ovarian cancer. This peptide is also produced by the mucosa of the gastrointestinal tract where it may protect the mucosal cells from proteolytic breakdown. The SPINK1 gene encodes pancreatic secretory trypsin inhibitor, which is secreted from pancreatic acinar cells into pancreatic juice. Its physiologic role was thought to be the prevention of trypsin-catalyzed premature activation of zymogens within the pancreas and the pancreatic duct. Mutations in this gene are associated with hereditary pancreatitis and tropical calcific pancreatitis.

Immunogen: Expression system for standard: E.coli; Immunogen sequence: D24-C79

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Reference:

Uniprot ID: P00995

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Cross Reactivity: There is no detectable cross-reactivity with other relevant proteins.

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Gene ID: 6690

Protein Name: Serine protease inhibitor Kazal-type 1

Gene Full Name: serine peptidase inhibitor Kazal type 1

Synonyms: PCTT; PSTI; SPINK1; Spink3; TaTI; TCP