Human Sphingosine-1-phosphate lyase 1,SGPL1 ELISA KIT

SKU: E7033Hu

Size:96 Tests-1 Kit

Background:Cleaves phosphorylated sphingoid bases (PSBs), such as sphingosine-1-phosphate, into fatty aldehydes and phosphoethanolamine. Elevates stress-induced ceramide production and apoptosis (PubMed:11018465, PubMed:14570870, PubMed:24809814, PubMed:28165339). Required for global lipid homeostasis in liver and cholesterol homeostasis in fibroblasts. Involved in the regulation of pro-inflammatory response and neutrophil trafficking. Modulates neuronal autophagy via phosphoethanolamine production which regulates accumulation of aggregate-prone proteins such as APP (By similarity). Seems to play a role in establishing neuronal contact sites and axonal maintenance (By similarity). {ECO:0000250|UniProtKB:Q8R0X7, ECO:0000250|UniProtKB:Q9V7Y2, ECO:0000269|PubMed:11018465, ECO:0000269|PubMed:14570870, ECO:0000269|PubMed:24809814, ECO:0000269|PubMed:28165339}.

Research_area:

Applications:ELISA

Target_protein:SGPL1

Reactivity:Human

Assay type:Sandwich

Sensitivity:57.25ng/L

Detection range:100-6400ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:O95470

MASS(Da):63524

GeneID:8879

Synonyms:SGPL1 KIAA1252

Gene names:SGPL1

Standard solution:12800ng/L