Human Snare-associated Protein Snapin, SNAPIN ELISA Kit

SKU: E6186Hu

Size:96 Tests-1 Kit

Background:Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking and synaptic vesicle recycling. May modulate a step between vesicle priming, fusion and calcium-dependent neurotransmitter release through its ability to potentiate the interaction of synaptotagmin with the SNAREs and the plasma-membrane-associated protein SNAP25. Its phosphorylation state influences exocytotic protein interactions and may regulate synaptic vesicle exocytosis. May also have a role in the mechanisms of SNARE-mediated membrane fusion in non-neuronal cells (PubMed:17182842, PubMed:18167355). As part of the BORC complex may play a role in lysosomes movement and localization at the cell periphery. Associated with the cytosolic face of lysosomes, the BORC complex may recruit ARL8B and couple lysosomes to microtubule plus-end-directed kinesin motor (PubMed:25898167).

Research_area:Others

Applications:ELISA

Target_protein:SNAPIN

Reactivity:Human

Assay type:Sandwich

Sensitivity:5.03ng/L

Detection range:10-2000ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:SNARE-associated protein Snapin

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:O95295

MASS(Da):14,874

GeneID:23557

Synonyms:Biogenesis of lysosome-related organelles complex 1 subunit 7;BLOC-1 subunit 7;BLOC1S7;BLOS7;BORCS3;SNAPAP;SNAP-associated protein;SNAPIN;SNARE-associated protein Snapin;Synaptosomal-associated protein 25-binding protein

Gene names:SNAPIN

Standard solution:2400ng/L