Human Small Ubiquitin-related Modifier 1, SUMO1 ELISA Kit

SKU: E6183Hu

Size:96 Tests-1 Kit

Background:Ubiquitin-like protein that can be covalently attached to proteins as a monomer or a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by E3 ligases such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Involved for instance in targeting RANGAP1 to the nuclear pore complex protein RANBP2. Covalently attached to the voltage-gated potassium Channel KCNB1; this modulates the gating characteristics of KCNB1 (PubMed: 19223394). Polymeric SUMO1 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins. May also regulate a network of genes involved in palate development. Covalently attached to ZFHX3 (PubMed: 24651376).

Research_area:Others

Applications:ELISA

Target_protein:SUMO1

Reactivity:Human

Assay type:Sandwich

Sensitivity:9.93ng/L

Detection range:20-4500ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Small Ubiquitin-Related Modifier 1

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:P63165

MASS(Da):11,557

GeneID:7341

Synonyms:GAP-modifying protein 1;GMP1;Sentrin;Small ubiquitin-related modifier 1;SMT3 homolog 3;Smt3C;SUMO 1;SUMO1;SUMO-1;Ubiquitin-homology domain protein PIC1;Ubiquitin-like protein SMT3C;Ubiquitin-like protein UBL1

Gene names:SUMO1

Standard solution:4800ng/L