Human Serpin A1/alpha 1-Antitrypsin EZ-Set™ ELISA Kit (DIY Antibody Pairs)

SKU: EZ1634

Size: 5 plates/kit

Storage: Store at 4℃ for 6 months, at -20℃ for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Form:

Reactivity: Human

Applications: ELISA

Application Details:

Gene Name: SERPINA1

Specificity: Natural and recombinant human Serpin A1

Background: Alpha-1-antitrypsin?or?α1-antitrypsin? (A1AT,?A1A, or?AAT) is a?protein?belonging to the?serpin?superfamily. It is encoded in humans by the?SERPINA1?gene.?The?gene?is located on the long arm of the fourteenth?chromosome? (14q32.1).The protein encoded by this gene is secreted and is a serine protease inhibitor whose targets include elastase, plasmin, thrombin, trypsin, chymotrypsin, and plasminogen activator. Defects in this gene can cause emphysema or liver disease. Several transcript variants encoding the same protein have been found for this gene.Like all?serine protease inhibitors, A1AT has a characteristic?secondary structure?of?beta sheets?and?alpha helices.?Mutations?in these areas can lead to non-functional proteins that can?polymerise?and accumulate in the?liver (infantile hepatic cirrhosis).

Immunogen: Expression system for standard: NS0; Immunogen sequence: E25-K418

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Reference:

Uniprot ID: P01009

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Cross Reactivity: There is no detectable cross-reactivity with other relevant proteins.

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Gene ID: 5265

Protein Name: Alpha-1-antitrypsin

Gene Full Name: serpin family A member 1

Synonyms: A1A; A-1-Antitrypsin; A1AT; AAT; Alpha 1 antiproteinase; Alpha 1 antitrypsin; Alpha 1 protease inhibitor; PI; PI1; PRO2209; PRO2275; Serpin A1; SERPINA1; SPAAT; α1-antitrypsin