Human Serine Threonine-protein Kinase Wnk2, WNK2 ELISA Kit

SKU: E6149Hu

Size:96 Tests-1 Kit

Background:Serine/threonine kinase which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival, and proliferation. Acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively. Activates SLC12A2, SCNN1A, SCNN1B, SCNN1D and SGK1 and inhibits SLC12A5. Negatively regulates the EGF-induced activation of the ERK/MAPK-pathway and the downstream cell cycle progression. Affects MAPK3/MAPK1 activity by modulating the activity of MAP2K1 and this modulation depends on phosphorylation of MAP2K1 by PAK1. WNK2 acts by interfering with the activity of PAK1 by controlling the balance of the activity of upstream regulators of PAK1 activity, RHOA and RAC1, which display reciprocal activity.

Research_area:Signal Transduction

Applications:ELISA

Target_protein:WNK2

Reactivity:Human

Assay type:Sandwich

Sensitivity:7.55ng/L

Detection range:15-3000ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Serine/threonine-protein kinase WNK2

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q9Y3S1

MASS(Da):242,676

GeneID:65268

Synonyms:Antigen NY-CO-43;NY-CO-43;P/OKcl.13;PRKWNK2;Protein kinase lysine-deficient 2;Protein kinase with no lysine 2;SDCCAG43;Serine/threonine-protein kinase WNK2;Serologically defined colon cancer antigen 43;WNK2

Gene names:WNK2

Standard solution:3200ng/L