Human Serine Threonine-protein Kinase Pim-3, PIM3 ELISA Kit

SKU: E2346Hu

Size:96 Tests-1 Kit

Background:Proto-oncogene with serine/threonine kinase activity that can prevent apoptosis, promote cell survival and protein translation. May contribute to tumorigenesis through: the delivery of survival signaling through phosphorylation of BAD which induces release of the anti-apoptotic protein Bcl-X(L), the regulation of cell cycle progression, protein synthesis and by regulation of MYC transcriptional activity. Additionally to this role on tumorigenesis, can also negatively regulate insulin secretion by inhibiting the activation of MAPK1/3 (ERK1/2), through SOCS6. Involved also in the control of energy metabolism and regulation of AMPK activity in modulating MYC and PPARGC1A protein levels and cell growth.

Research_area:Signal Transduction; Epigenetics and Nuclear Signaling; Cancer

Applications:ELISA

Target_protein:PIM3

Reactivity:Human

Assay type:Sandwich

Sensitivity:13.15ng/L

Detection range:20-4500ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:serine/threonine-protein kinase pim-3

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q86V86

MASS(Da):35,891

GeneID:415116

Synonyms:PIM3;pim-3;Serine/threonine-protein kinase pim-3

Gene names:PIM3

Standard solution:4800ng/L