Human SEMA6D ELISA Kit PicoKine®

SKU: EK2060

Size: 96 wells/kit, with removable strips.

Storage: Store at 4℃ for 6 months, at -20℃ for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Form:

Reactivity: Human

Applications: ELISA

Application Details:

Gene Name: SEMA6D

Specificity: Natural and recombinant human SEMA6D

Background: Semaphorin 6D (Sema6D) is a 130 ? 135 kDa member of the Semaphorin family of axon guidance molecules. This gene is mapped to 15q21.1. Semaphorins are a large family, including both secreted and membrane associated proteins, many of which have been implicated as inhibitors or chemorepellents in axon pathfinding, fasciculation and branching, and target selection. All semaphorins possess a semaphorin (Sema) domain and a PSI domain (found in plexins, semaphorins and integrins) in the N-terminal extracellular portion. Additional sequence motifs C-terminal to the semaphorin domain allow classification into distinct subfamilies. Results demonstrate that transmembrane semaphorins, like the secreted ones, can act as repulsive axon guidance cues. This gene encodes a class 6 vertebrate transmembrane semaphorin that demonstrates alternative splicing. Several transcript variants have been identified and expression of the distinct encoded isoforms is thought to be regulated in a tissue- and development-dependent manner.

Immunogen: Expression system for standard: NS0; Immunogen sequence: V21-N662

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Reference:

Uniprot ID: Q8NFY4

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Cross Reactivity: There is no detectable cross-reactivity with other relevant proteins.

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Gene ID: 80031

Protein Name: Semaphorin-6D

Gene Full Name: semaphorin 6D

Synonyms: Semaphorin-6D; SEMA6D; KIAA1479