Human Roundabout Homolog 1, ROBO1 ELISA Kit

SKU: E6105Hu

Size:96 Tests-1 Kit

Background:Receptor for SLIT1 and SLIT2 that mediates cellular responses to molecular guidance cues in cellular migration, including axonal navigation at the ventral midline of the neural tube and projection of axons to different regions during neuronal development (PubMed: 10102268, PubMed: 24560577). Interaction with the intracellular domain of FLRT3 mediates axon attraction towards cells expressing NTN1 (PubMed: 24560577). In axon growth cones, the silencing of the attractive effect of NTN1 by SLIT2 may require the formation of a ROBO1-DCC complex (By similarity). Plays a role in the regulation of cell migration via its interaction with MYO9B; inhibits MYO9B-mediated stimulation of RHOA GTPase activity, and thereby leads to increased levels of active, GTP-bound RHOA (PubMed: 26529257). May be required for lung development (By similarity).

Research_area:Cancer

Applications:ELISA

Target_protein:ROBO1

Reactivity:Human

Assay type:Sandwich

Sensitivity:0.025ng/mL

Detection range:0.05-20ng/mL

Sample type:Serum, plasma or other biological fluids

Full product name:Roundabout Homolog 1

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q9Y6N7

MASS(Da):180,930

GeneID:6091

Synonyms:Deleted in U twenty twenty;H-Robo-1;ROBO 1;ROBO1;Roundabout homolog 1

Gene names:ROBO1

Standard solution:24ng/mL