Human Rho Guanine Nucleotide Exchange Factor 4, ARHGEF4 ELISA Kit

SKU: E3237Hu

Size:96 Tests-1 Kit

Background:Acts as guanine nucleotide exchange factor (GEF) for RHOA, RAC1 and CDC42 GTPases. Binding of APC may activate RAC1 GEF activity. The APC-ARHGEF4 complex seems to be involved in cell migration as well as in E-cadherin-mediated cell-cell adhesion. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Involved in tumor angiogenesis and may play a role in intestinal adenoma formation and tumor progression.

Research_area:Others

Applications:ELISA

Target_protein:ARHGEF4

Reactivity:Human

Assay type:Sandwich

Sensitivity:3.14ng/L

Detection range:5-1000ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Rho Guanine Nucleotide Exchange Factor 4

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q9NR80

MASS(Da):79,067

GeneID:50649

Synonyms:APC-stimulated guanine nucleotide exchange factor 1;ARHGEF4;ASEF;ASEF1;GEF4;Rho guanine nucleotide exchange factor 4;SMIM39;STM6

Gene names:ARHGEF4

Standard solution:1280ng/L