Human Receptor-type Tyrosine-protein Phosphatase N2, PTPRN2 ELISA Kit

SKU: E6069Hu

Size:96 Tests-1 Kit

Background:Plays a role in vesicle-mediated secretory processes. Required for normal accumulation of secretory vesicles in hippocampus, pituitary and pancreatic islets. Required for the accumulation of normal levels of insulin-containing vesicles and preventing their degradation. Plays a role in insulin secretion in response to glucose stimuli. Required for normal accumulation of the neurotransmitters norepinephrine, dopamine and serotonin in the brain. In females, but not in males, required for normal accumulation and secretion of pituitary hormones, such as luteinizing hormone (LH) and follicle-stimulating hormone (FSH) (By similarity). Required to maintain normal levels of renin expression and renin release (By similarity). May regulate catalytic active protein-tyrosine phosphatases such as PTPRA through dimerization (By similarity). Has phosphatidylinositol phosphatase activity; the PIPase activity is involved in its ability to regulate insulin secretion. Can dephosphorylate phosphatidylinositol 4,5-biphosphate (PI(4,5)P2), phosphatidylinositol 5-phosphate and phosphatidylinositol 3-phosphate (By similarity). Regulates PI(4,5)P2 level in the plasma membrane and localization of cofilin at the plasma membrane and thus is indirectly involved in regulation of actin dynamics related to cell migration and metastasis; upon hydrolyzation of PI(4,5)P2 cofilin is released from the plasma membrane and acts in the cytoplasm in severing F-actin filaments (PubMed:26620550).

Research_area:Others

Applications:ELISA

Target_protein:PTPRN2

Reactivity:Human

Assay type:Sandwich

Sensitivity:0.056ng/mL

Detection range:0.1-40ng/mL

Sample type:Serum, plasma or other biological fluids

Full product name:Receptor-type tyrosine-protein phosphatase N2

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q92932

MASS(Da):111,271

GeneID:5799

Synonyms:IA-2beta;IA-2beta60];IAR;ICAAR;Islet cell autoantigen-related protein;Phogrin;PTPRN2;PTPRP;Receptor-type tyrosine-protein phosphatase N2;R-PTP-N2

Gene names:PTPRN2

Standard solution:48ng/mL