Human Ras-related Protein Rab-11A, RAB11A ELISA Kit

SKU: E7270Hu

Size:96 Tests-1 Kit

Background:The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. The small Rab GTPase RAB11A regulates endocytic recycling. Acts as a major regulator of membrane delivery during cytokinesis. Together with MYO5B and RAB8A participates in epithelial cell polarization. Together with RAB3IP, RAB8A, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis. Together with MYO5B participates in CFTR trafficking to the plasma membrane and TF (Transferrin) recycling in nonpolarized cells. Required in a complex with MYO5B and RAB11FIP2 for the transport of NPC1L1 to the plasma membrane. Participates in the sorting and basolateral transport of CDH1 from the Golgi apparatus to the plasma membrane. Regulates the recycling of FCGRT (receptor of Fc region of monomeric Ig G) to basolateral membranes. May also play a role in melanosome transport and release from melanocytes.

Research_area:Signal Transduction

Applications:ELISA

Target_protein:RAB11A

Reactivity:Human

Assay type:Sandwich

Sensitivity:0.31ng/ml

Detection range:0.5-150ng/ml

Sample type:Serum, plasma or other biological fluids

Full product name:Ras-Related Protein Rab-11A

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:P62491

MASS(Da):24,394

GeneID:8766

Synonyms:Rab-11;RAB11A;Ras-related protein Rab-11A;YL8

Gene names:RAB11A

Standard solution:160ng/ml