Human Rapamycin Insensitive Companion of Mtor, RICTOR ELISA Kit

SKU: E3592Hu

Size:96 Tests-1 Kit

Background:Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1 at 'Ser-422'. mTORC2 also modulates the phosphorylation of PRKCA on 'Ser-657'. Plays an essential role in embryonic growth and development.

Research_area:Cell Biology

Applications:ELISA

Target_protein:RICTOR

Reactivity:Human

Assay type:Sandwich

Sensitivity:0.028ng/ml

Detection range:0.05-15ng/ml

Sample type:Serum, plasma or other biological fluids

Full product name:Rapamycin insensitive companion of mTOR

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q6R327

MASS(Da):192,218

GeneID:253260

Synonyms:AVO3;AVO3 homolog;hAVO3;PIA;Rapamycin-insensitive companion of mTOR;RICTOR

Gene names:RICTOR

Standard solution:16ng/ml