Human R-Spondin1 PicoKine® Quick ELISA Kit

SKU: FEK1516

Size: 96 wells/kit, with removable strips.

Storage: Store at 4°C for 6 months. (Ships with gel ice, can store for up to 3 days in room temperature. Refrigerate upon receipt.)

Form:

Reactivity: Human

Applications: ELISA

Application Details:

Gene Name: RSPO1

Specificity: Natural and recombinant human R-Spondin-1

Background: R-spondin-1 is a secreted protein that in humans is encoded by the Rspo1 gene. It is mapped to chromosome 1p34. This gene encodes a secreted activator protein with two cysteine-rich, furin-like domains and one thrombospondin type 1 domain. The encoded protein is a ligand for leucine-rich repeat-containing G-protein coupled receptors (LGR proteins) and positively regulates the Wnt signaling pathway. In mice, the protein induces the rapid onset of crypt cell proliferation and increases intestinal epithelial healing, providing a protective effect against chemotherapy- induced adverse effects. Alternative splicing results in multiple transcript variants.

Immunogen: Expression system for standard: NS0; Immunogen sequence: S21-A263

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Reference:

Uniprot ID: Q2MKA7

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Cross Reactivity: There is no detectable cross-reactivity with other relevant proteins.

Isotype:

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Gene ID: 284654

Protein Name: R-spondin-1

Gene Full Name: R-spondin 1

Synonyms: CRISTIN3; hRspo1; R spondin 1; Roof plate specific spondin 1; RSPO; RSPO1