Human R-Spondin-1, RSPO1 ELISA Kit

SKU: E6107Hu

Size:96 Tests-1 Kit

Background:Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors (PubMed: 29769720). Upon binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Also regulates the canonical Wnt/beta-catenin-dependent pathway and non-canonical Wnt signaling by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. Acts as a ligand for frizzled FZD8 and LRP6. May negatively regulate the TGF-beta pathway. Has a essential roles in ovary determination. Regulates Wnt signaling by antagonizing DKK1/KREM1-mediated internalization of LRP6 through an interaction with KREM1 (PubMed: 17804805).

Research_area:Developmental Biology

Applications:ELISA

Target_protein:RSPO1

Reactivity:Human

Assay type:Sandwich

Sensitivity:9.52ng/L

Detection range:20-7000ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:R-Spondin-1

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q2MKA7

MASS(Da):28,959

GeneID:284654

Synonyms:hRspo1;Roof plate-specific spondin-1;RSPO 1;RSPO1;R-spondin-1

Gene names:RSPO1

Standard solution:8000ng/L