Human Pyruvate Dehydrogenase Kinase Isozyme 1,PDK1 ELISA KIT

SKU: E7349Hu

Size:96 Tests-1 Kit

Background:Kinase that plays a key role in regulation of glucose and fatty acid metabolism and homeostasis via phosphorylation of the pyruvate dehydrogenase subunits PDHA1 and PDHA2. This inhibits pyruvate dehydrogenase activity, and thereby regulates metabolite flux through the tricarboxylic acid cycle, down-regulates aerobic respiration and inhibits the formation of acetyl-coenzyme A from pyruvate. Plays an important role in cellular responses to hypoxia and is important for cell proliferation under hypoxia. Protects cells against apoptosis in response to hypoxia and oxidative stress. {ECO:0000269|PubMed:17683942, ECO:0000269|PubMed:18541534, ECO:0000269|PubMed:22195962, ECO:0000269|PubMed:7499431}.

Research_area:

Applications:ELISA

Target_protein:PDK1

Reactivity:Human

Assay type:Sandwich

Sensitivity:0.016ng/ml

Detection range:0.05-10ng/ml

Sample type:Serum, plasma or other biological fluids

Full product name:Pyruvate Dehydrogenase Kinase Isozyme 1

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q15118

MASS(Da):49244

GeneID:5163

Synonyms:PDK1 PDHK1

Gene names:PDK1

Standard solution:12.8ng/ml