Human Pyrin, MEFV ELISA Kit

SKU: E6050Hu

Size:96 Tests-1 Kit

Background:Involved in the regulation of innate immunity and the inflammatory response in response to IFNG/IFN-gamma. Organizes autophagic machinery by serving as a platform for the assembly of ULK1, Beclin 1/BECN1, ATG16L1, and ATG8 family members and recognizes specific autophagy targets, thus coordinating target recognition with assembly of the autophagic apparatus and initiation of autophagy. Acts as an autophagy receptor for the degradation of several inflammasome components, including CASP1, NLRP1 and NLRP3, hence preventing excessive IL1B- and IL18-mediated inflammation (PubMed:16785446, PubMed:17431422, PubMed:26347139). However, it can also have a positive effect in the inflammatory pathway, acting as an innate immune sensor that triggers PYCARD/ASC specks formation, caspase-1 activation, and IL1B and IL18 production (PubMed:16037825, PubMed:27030597, PubMed:28835462). It is required for PSTPIP1-induced PYCARD/ASC oligomerization and inflammasome formation. Recruits PSTPIP1 to inflammasomes, and is required for PSTPIP1 oligomerization (PubMed:10807793, PubMed:11468188, PubMed:17964261, PubMed:18577712, PubMed:19109554, PubMed:19584923).

Research_area:Others

Applications:ELISA

Target_protein:MEFV

Reactivity:Human

Assay type:Sandwich

Sensitivity:7.96ng/L

Detection range:15-3000ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Pyrin

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:O15553

MASS(Da):86,444

GeneID:4210

Synonyms:FMF;Marenostrin;MEF;MEFV;PAAND;Pyrin;TRIM20

Gene names:MEFV

Standard solution:3200ng/L