Human Proto-oncogene Tyrosine-protein Kinase Receptor Ret, RET ELISA Kit

SKU: E6033Hu

Size:96 Tests-1 Kit

Background:Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. Phosphorylates PTK2/FAK1. Regulates both cell death/survival balance and positional information. Required for the molecular mechanisms orchestration during intestine organogenesis; involved in the development of enteric nervous system and renal organogenesis during embryonic life, and promotes the formation of Peyer's patch-like structures, a major component of the gut-associated lymphoid tissue. Modulates cell adhesion via its cleavage by caspase in sympathetic neurons and mediates cell migration in an integrin (e.g. ITGB1 and ITGB3)-dependent manner. Involved in the development of the neural crest. Active in the absence of ligand, triggering apoptosis through a mechanism that requires receptor intracellular caspase cleavage. Acts as a dependence receptor; in the presence of the ligand GDNF in somatotrophs (within pituitary), promotes survival and down regulates growth hormone (GH) production, but triggers apoptosis in absence of GDNF. Regulates nociceptor survival and size. Triggers the differentiation of rapidly adapting (RA) mechanoreceptors. Mediator of several diseases such as neuroendocrine cancers; these diseases are characterized by aberrant integrins-regulated cell migration. Mediates, through interaction with GDF15-receptor GFRAL, GDF15-induced cell-signaling in the brainstem which induces inhibition of food-intake. Activates MAPK- and AKT-signaling pathways (PubMed:28846097, PubMed:28953886, PubMed:28846099). Isoform 1 in complex with GFRAL induces higher activation of MAPK-signaling pathway than isoform 2 in complex with GFRAL (PubMed:28846099).

Research_area:Others

Applications:ELISA

Target_protein:RET

Reactivity:Human

Assay type:Sandwich

Sensitivity:0.058ng/mL

Detection range:0.1-40ng/mL

Sample type:Serum, plasma or other biological fluids

Full product name:Proto-oncogene tyrosine-protein kinase receptor Ret

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:P07949

MASS(Da):124,319

GeneID:5979

Synonyms:Cadherin family member 12;CDHF12;Extracellular cell-membrane anchored RET cadherin 120 kDa fragment];HSCR1;MEN2A;MEN2B;MTC1;Proto-oncogene c-Ret;Proto-oncogene tyrosine-protein kinase receptor Ret;PTC;RET;RET-ELE1;Soluble RET kinase fragment;

Gene names:RET

Standard solution:48ng/mL