Human Protein Hexim1, HEXIM1 ELISA Kit

SKU: E5980Hu

Size:96 Tests-1 Kit

Background:Transcriptional regulator which functions as a general RNA polymerase II transcription inhibitor (PubMed:14580347, PubMed:15713661, PubMed:15201869). Core component of the 7SK RNP complex: in cooperation with 7SK snRNA sequesters P-TEFb in a large inactive 7SK snRNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation (PubMed:12832472, PubMed:14580347, PubMed:15713661, PubMed:15201869). May also regulate NF-kappa-B, ESR1, NR3C1 and CIITA-dependent transcriptional activity (PubMed:15940264, PubMed:15941832, PubMed:17088550). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728).

Research_area:Epigenetics and Nuclear Signaling

Applications:ELISA

Target_protein:HEXIM1

Reactivity:Human

Assay type:Sandwich

Sensitivity:9.61ng/L

Detection range:20-4500ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Protein HEXIM1

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:O94992

MASS(Da):40,623

GeneID:10614

Synonyms:Cardiac lineage protein 1;CLP1;EDG1;Estrogen down-regulated gene 1 protein;Hexamethylene bis-acetamide-inducible protein 1;HEXIM1;HIS1;MAQ1;Menage a quatre protein 1;Protein HEXIM1

Gene names:HEXIM1

Standard solution:4800ng/L