Human Protein Disulfide Isomerase, PDI ELISA Kit

SKU: E0883Hu

Size:96 Tests-1 Kit

Background:This multifunctional protein catalyzes the formation, breakage and rearrangement of disulfide bonds. At the cell surface, seems to act as a reductase that cleaves disulfide bonds of proteins attached to the cell. May therefore cause structural modifications of exofacial proteins. Inside the cell, seems to form/rearrange disulfide bonds of nascent proteins. At high concentrations, functions as a chaperone that inhibits aggregation of misfolded proteins. At low concentrations, facilitates aggregation (anti-chaperone activity). May be involved with other chaperones in the structural modification of the TG precursor in hormone biogenesis. Also acts a structural subunit of various enzymes such as prolyl 4-hydroxylase and microsomal triacylglycerol transfer protein MTTP. Receptor for LGALS9; the interaction retains P4HB at the cell surface of Th2 T helper cells, increasing disulfide reductase activity at the plasma membrane, altering the plasma membrane redox state and enhancing cell migration (PubMed:21670307).

Research_area:Others

Applications:ELISA

Target_protein:PDI

Reactivity:Human

Assay type:Sandwich

Sensitivity:0.055ng/mL

Detection range:0.1-40ng/mL

Sample type:Serum, plasma or other biological fluids

Full product name:protein disulfide isomerase

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:P07237

MASS(Da):57,116

GeneID:5034

Synonyms:Cellular thyroid hormone-binding protein;CLCRP1;DSI;ERBA2L;GIT;P4Hbeta;p55;PDI;PDIA1;PHDB;PO4DB;PROHB;Prolyl 4-hydroxylase subunit beta;Protein disulfide-isomerase

Gene names:P4HB

Standard solution:48ng/mL