Human Protein Cereblon, CRBN ELISA Kit

SKU: E2888Hu

Size:96 Tests-1 Kit

Background:Substrate recognition component of a DCX (DDB1-CUL4-X-box) E3 protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as MEIS2 (Probable). Normal degradation of key regulatory proteins is required for normal limb outgrowth and expression of the fibroblast growth factor FGF8 (PubMed: 20223979, PubMed: 24328678, PubMed: 25043012, PubMed: 25108355). Maintains presynaptic glutamate release and consequently cognitive functions, such as memory and learning, by negatively regulating large-conductance calcium-activated potassium (BK) Channels in excitatory neurons (PubMed: 18414909, PubMed: 29530986). Likely to function by regulating the assembly and neuronal surface expression of BK Channels via its interaction with KCNT1 (PubMed: 18414909). May also be involved in regulating anxiety-like behaviors via a BK Channel-independent mechanism (By similarity).

Research_area:Neuroscience

Applications:ELISA

Target_protein:CRBN

Reactivity:Human

Assay type:Sandwich

Sensitivity:0.043ng/ml

Detection range:0.1-40ng/ml

Sample type:Serum, plasma or other biological fluids

Full product name:Protein Cereblon

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q96SW2

MASS(Da):50,546

GeneID:51185

Synonyms:CRBN;Protein cereblon

Gene names:CRBN

Standard solution:48ng/ml