Human Protein-arginine Deiminase Type-1, PADI1 ELISA Kit

SKU: E4080hu

Size:96 Tests-1 Kit

Background:Peptidyl arginine deiminase, type I, also known as PADI1, is a protein which in humans is encoded by the PADI1 gene. This gene encodes a member of the peptidyl arginine deiminase family of enzymes, which catalyze the post-translational deimination of proteins by converting arginine residues into citrullines in the presence of calcium ions. The family members have distinct substrate specificities and tissue-specific expression patterns. The type I enzyme is involved in the late stages of epidermal differentiation, where it deiminates filaggrin and keratin K1, which maintains hydration of the stratum corneum, and hence the cutaneous barrier function. This enzyme may also play a role in hair follicle formation. This gene exists in a cluster with four other paralogous genes.

Research_area:Signal Transduction

Applications:ELISA

Target_protein:PADI1

Reactivity:Human

Assay type:Sandwich

Sensitivity:0.049ng/ml

Detection range:0.1-40ng/ml

Sample type:Serum, plasma or other biological fluids

Full product name:protein-arginine deiminase type-1

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q9ULC6

MASS(Da):74,666

GeneID:29943

Synonyms:HPAD10;PAD1;PADI1;PDI;PDI1;Peptidylarginine deiminase I;Protein-arginine deiminase type I;Protein-arginine deiminase type-1

Gene names:PADI1

Standard solution:40ng/ml