Human Protection of Telomeres Protein 1, POT1 ELISA Kit

SKU: E5950Hu

Size:96 Tests-1 Kit

Background:Component of the telomerase ribonucleoprotein (RNP) complex that is essential for the replication of chromosome termini. Is a component of the double-stranded telomeric DNA-binding TRF1 complex which is involved in the regulation of telomere length by cis-inhibition of telomerase. Also acts as a single-stranded telomeric DNA-binding protein and thus may act as a downstream effector of the TRF1 complex and may transduce information about telomere maintenance and/or length to the telomere terminus. Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Binds to two or more telomeric single-stranded 5'-TTAGGG-3' repeats (G-strand) and with high specificity to a minimal telomeric single-stranded 5'-TAGGGTTAG-3' sequence. Binds telomeric single-stranded sequences internally or at proximity of a 3'-end. Its activity is TERT dependent but it does not increase TERT activity by itself. In contrast, the ACD-POT1 heterodimer enhances telomere elongation by increasing telomerase processivity.

Research_area:Epigenetics and Nuclear Signaling

Applications:ELISA

Target_protein:POT1

Reactivity:Human

Assay type:Sandwich

Sensitivity:9.64ng/L

Detection range:20-6000ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Protection of Telomeres Protein 1

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q9NUX5

MASS(Da):71,442

GeneID:25913

Synonyms:hPot1;POT 1;POT1;POT1-like telomere end-binding protein;Protection of telomeres protein 1

Gene names:POT1

Standard solution:6400ng/L