Human Probable ATP-dependent RNA helicase DDX20,DDX20 ELISA KIT

SKU: E3538Hu

Size:96 Tests-1 Kit

Background:The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their transport to the nucleus. May also play a role in the metabolism of small nucleolar ribonucleoprotein (snoRNPs). {ECO:0000269|PubMed:18984161}.

Research_area:

Applications:ELISA

Target_protein:DDX20

Reactivity:Human

Assay type:Sandwich

Sensitivity:0.13ng/ml

Detection range:0.25-16ng/ml

Sample type:Serum, plasma or other biological fluids

Full product name:Probable ATP-dependent RNA helicase DDX20

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q9UHI6

MASS(Da):92241

GeneID:11218

Synonyms:DDX20 DP103 GEMIN3

Gene names:DDX20

Standard solution:32ng/ml