Human Phosphatidylinositol 3-kinase Regulatory Subunit Bbeta, PIK3R2 ELISA Kit

SKU: E5865Hu

Size:96 Tests-1 Kit

Background:Regulatory subunit of phosphoinositide-3-kinase (PI3K), a kinase that phosphorylates PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Binds to activated (phosphorylated) protein-tyrosine kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Indirectly regulates autophagy (PubMed:23604317). Promotes nuclear translocation of XBP1 isoform 2 in a ER stress- and/or insulin-dependent manner during metabolic overloading in the liver and hence plays a role in glucose tolerance improvement (By similarity).

Research_area:Signal Transduction; Immunology

Applications:ELISA

Target_protein:PIK3R2

Reactivity:Human

Assay type:Sandwich

Sensitivity:6.96ng/L

Detection range:15-3000ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Phosphatidylinositol 3-kinase regulatory subunit beta

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:O00459

MASS(Da):81,545

GeneID:5296

Synonyms:MPPH;MPPH1;p85;P85B;p85-BETA;Phosphatidylinositol 3-kinase 85 kDa regulatory subunit beta;Phosphatidylinositol 3-kinase regulatory subunit beta;PI3K regulatory subunit beta;PI3-kinase regulatory subunit beta;PI3-kinase subunit p85-beta;PIK3R2;PtdIns-3-kinase regulatory subunit beta;PtdIns-3-kinase regulatory subunit p85-beta;

Gene names:PIK3R2

Standard solution:3200ng/L