Human Peroxisome Proliferator-activated Receptor Gamma, PPARG ELISA Kit

SKU: E1511Hu

Size:96 Tests-1 Kit

Background:Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut homeostasis by suppressing NF-kappa-B-mediated proinflammatory responses. Plays a role in the regulation of cardiovascular circadian rhythms by regulating the transcription of ARNTL/BMAL1 in the blood vessels (By similarity). (Microbial infection) Upon treatment with M.tuberculosis or its lipoprotein LpqH, phosphorylation of MAPK p38 and IL-6 production are modulated, probably via this protein.

Research_area:Metabolism

Applications:ELISA

Target_protein:PPARG

Reactivity:Human

Assay type:Sandwich

Sensitivity:14.16ng/L

Detection range:30-9000ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Peroxisome Proliferator-Activated Receptor Gamma

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:P37231

MASS(Da):57,620

GeneID:5468

Synonyms:Nuclear receptor subfamily 1 group C member 3;Peroxisome proliferator-activated receptor gamma;PPARG;PPAR-gamma

Gene names:PPARG

Standard solution:9600ng/L