Human PCSK9/Proprotein Convertase 9 ELISA Kit PicoKine®

SKU: EK1147

Size: 96 wells/kit, with removable strips.

Storage: Store at 4℃ for 6 months, at -20℃ for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Form:

Reactivity: Human

Applications: ELISA

Application Details:

Gene Name: PCSK9

Specificity: Natural and recombinant human PCSK9

Background: Proprotein convertase subtilisin/kexin type 9, also known as PCSK9, is an enzyme that in humans is encoded by the PCSK9 gene. This gene encodes a proprotein convertase belonging to the proteinase K subfamily of the secretory subtilase family. By genomic sequence analysis, the PCSK9 gene was mapped to chromosome 1p32. This protein plays a major regulatory role in cholesterol homeostasis. PCSK9 binds to the epidermal growth factor-like repeat A (EGF-A) domain of the low-density lipoprotein receptor (LDLR), inducing LDLR degradation. Reduced LDLR levels result in decreased metabolism of low-density lipoproteins (LDL), which could lead to hypercholesterolemia. PCSK9 may also have a role in the differentiation of cortical neurons.

Immunogen: Expression system for standard: NS0; Immunogen sequence: S153-Q692

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Reference:

Uniprot ID: Q8NBP7

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Cross Reactivity: There is no detectable cross-reactivity with other relevant proteins.

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Gene ID: 255738

Protein Name: Proprotein convertase subtilisin/kexin type 9

Gene Full Name: proprotein convertase subtilisin/kexin type 9

Synonyms: FH3; HCHOLA3; LDLCQ1; NARC 1; NARC1; PC9; PCSK9; Proprotein convertase 9