Human PAI-1 ELISA Kit PicoKine®

SKU: EK0859

Size: 96 wells/kit, with removable strips.

Storage: Store at 4℃ for 6 months, at -20℃ for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Form:

Reactivity: Human

Applications: ELISA

Application Details:

Gene Name: SERPINE1

Specificity: Natural and recombinant human PAI-1

Background: Plasminogen activator inhibitor-1 is the principal inhibitor of tissue plasminogen activator (tPA) and urokinase (uPA), the activators of plasminogen and hence fibrinolysis (the physiological breakdown of blood clots). It is a serine protease inhibitor (serpin) protein (SERPINE1). PAI-1 is mainly produced by the endothelium (cells lining blood vessels), but is also secreted by other tissue types, such as adipose tissue. The PAI-1 gene is located on the seventh chromosome (7q21.3-q22).1 Congenital deficiency of PAI-1 leads to a hemorrhagic diathesis (a tendency to hemorrhage). PAI-1 is present in increased levels in various disease states (such as a number of forms of cancer), as well as in obesity and the metabolic syndrome. It has been linked to the increased occurrence of thrombosis in patients with these conditions. Additionally, it has been shown to interact with ORM1.2 The standard product used in this kit is recombinant human PAI-1 with the molecular mass of 43KDa.

Immunogen: Expression system for standard: NS0; Immunogen sequence: S22-P402

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Reconstitution:

Reference:

Uniprot ID: P05121

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Cross Reactivity: There is no detectable cross-reactivity with other relevant proteins.

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Gene ID: 5054

Protein Name: Plasminogen activator inhibitor 1

Gene Full Name: serpin family E member 1

Synonyms: PAI; PAI 1; PAI1; PAI-1; PLANH1; Serpin E1; SERPINE1; PAI-1