Human Opsin 5, OPN5 ELISA Kit

SKU: E2414Hu

Size:96 Tests-1 Kit

Background:G-protein coupled receptor which selectively activates G(i) type G proteins via ultraviolet A (UVA) light-mediated activation in the retina (By similarity). Preferentially binds the chromophore 11-cis retinal and is a bistable protein that displays emission peaks at 380 nm (UVA light) and 470 nm (blue light) (PubMed: 22043319). Required for the light-response in the inner plexiform layer, and contributes to the regulation of the light-response in the nerve fiber layer, via phosphorylated DAT/SLC6A3 dopamine uptake (By similarity). Involved in local corneal and retinal circadian rhythm photoentrainment via modulation of the UVA light-induced phase-shift of the retina clock (By similarity). Acts as a circadian photoreceptor in the outer ear, via modulation of circadian clock-gene expression in response to violet light during the light-to-dark transition phase and night phase of the circadian cycle (By similarity). Required in the retina to negatively regulate hyaloid vessel regression during postnatal development via light-dependent OPN5-SLC32A1-DRD2-VEGFR2 signaling (By similarity). Involved in the light-dependent regulation of retina and vitreous compartment dopamine levels (By similarity).

Research_area:Neuroscience; Cardiovascular

Applications:ELISA

Target_protein:OPN5

Reactivity:Human

Assay type:Sandwich

Sensitivity:0.07ng/ml

Detection range:0.2-60ng/ml

Sample type:Serum, plasma or other biological fluids

Full product name:Opsin 5

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q6U736

MASS(Da):39,727

GeneID:221391

Synonyms:G-protein coupled receptor 136;G-protein coupled receptor PGR12;Neuropsin;OPN 5;OPN5;Opsin-5;Transmembrane protein 13

Gene names:OPN5

Standard solution:80ng/ml