Human Nkg2-C Type 2 Integral Membrane Protein, KLRC2 ELISA Kit

SKU: E5778Hu

Size:96 Tests-1 Kit

Background:Immune activating receptor involved in self-nonself discrimination. In complex with KLRD1 on cytotoxic lymphocyte subsets, recognizes non-classical major histocompatibility (MHC) class Ib HLA-E loaded with signal sequence-derived peptides from non-classical MHC class Ib HLA-G molecules, likely playing a role in the generation and effector functions of adaptive natural killer (NK) cells and in maternal-fetal tolerance during pregnancy (PubMed:9754572, PubMed:30134159). Regulates the effector functions of terminally differentiated cytotoxic lymphocyte subsets, and in particular may play a role in adaptive NK cell response to viral infection (PubMed:21825173, PubMed:20952657). Upon HLA-E-peptide binding, transmits intracellular signals via the adapter protein TYROBP/DAP12, triggering the phosphorylation of proximal signaling molecules and cell activation (PubMed:9655483, PubMed:15940674).

Research_area:Cancer

Applications:ELISA

Target_protein:KLRC2

Reactivity:Human

Assay type:Sandwich

Sensitivity:0.019ng/mL

Detection range:0.05-20ng/mL

Sample type:Serum, plasma or other biological fluids

Full product name:NKG2-C type 2 integral membrane protein

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:P26717

MASS(Da):26,072

GeneID:3822

Synonyms:CD antigen CD159c;CD159 antigen-like family member C;CD159c;KLRC2;NK cell receptor C;NKG2C;NKG2-C;NKG2-C type II integral membrane protein;NKG2-C-activating NK receptor;

Gene names:KLRC2

Standard solution:24ng/mL