Human Neuropilin-1 EZ-Set™ ELISA Kit (DIY Antibody Pairs)

SKU: EZ1353

Size: 5 plates/kit

Storage: Store at 4℃ for 6 months, at -20℃ for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Form:

Reactivity: Human

Applications: ELISA

Application Details:

Gene Name: NRP1

Specificity: Natural and recombinant human Neuropilin-1

Background: NRP1 (Neuropilin 1) also known as NP1, NRP, BDCA4 or VEGF165R, is a membrane-bound coreceptor to a tyrosine kinase receptor for both vascular endothelial growth factor (VEGF) and semaphorin family members. NRP1 plays versatile roles in angiogenesis, axon guidance, cell survival, migration, and invasion. By somatic cell hybrid analysis, the NRP1 gene was mapped to chromosome 10. NRP1 bounds PGF1 with lower affinity. NRP1-mediated interactions are a necessary element in the initiation of the primary immune response and offer another example, like that of agrin, of a molecule shared by neurologic and immunologic synapses. After T-cell contact with DC, T-cell NRP1 colocalized with CD3 in the immunologic synapse and, sometimes, also at the opposite pole of the T cell. Soluble NRP1 interacts in a homophilic fashion with NRP1 on both DC and T cells, and this binding can be inhibited by blocking antibodies to NRP1. Furthermore, selective NRP1 inhibition in this model suppressed neovascular formation substantially.

Immunogen: Expression system for standard: NS0; Immunogen sequence: F22-K644

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Uniprot ID: O14786

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Cross Reactivity: There is no detectable cross-reactivity with other relevant proteins.

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Gene ID: 8829

Protein Name: Neuropilin-1

Gene Full Name: neuropilin 1

Synonyms: neuropilin 1; BDCA4; CD304; NP1; NRP; VEGF165R; Neuropilin-1; NRP1