Human Neurogenic Differentiation Factor 2, NEUROD2 ELISA Kit

SKU: E2921Hu

Size:96 Tests-1 Kit

Background:Transcriptional regulator implicated in neuronal determination. Mediates calcium-dependent transcription activation by binding to E box-containing promoter. Critical factor essential for the repression of the genetic program for neuronal differentiation; prevents the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. Induces transcription of ZEB1, which in turn represses neuronal differentiation by down-regulating REST expression. Plays a role in the establishment and maturation of thalamocortical connections; involved in the segregation of thalamic afferents into distinct barrel domains within layer VI of the somatosensory cortex. Involved in the development of the cerebellar and hippocampal granular neurons, neurons in the basolateral nucleus of amygdala and the hypothalamic-pituitary axis. Associates with chromatin to the DPYSL3 E box-containing promoter (By similarity).

Research_area:Epigenetics and Nuclear Signaling

Applications:ELISA

Target_protein:NEUROD2

Reactivity:Human

Assay type:Sandwich

Sensitivity:0.021ng/ml

Detection range:0.05-15ng/ml

Sample type:Serum, plasma or other biological fluids

Full product name:Neurogenic differentiation factor 2

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q15784

MASS(Da):41,361

GeneID:4761

Synonyms:bHLHa1;Class A basic helix-loop-helix protein 1;DEE72;EIEE72;NDRF;NEUROD2;NeuroD-related factor;Neurogenic differentiation factor 2

Gene names:NEUROD2

Standard solution:16ng/ml