Human Neurexin 1, NRXN1 ELISA Kit

SKU: E3987Hu

Size:96 Tests-1 Kit

Background:Cell surface protein involved in cell-cell-interactions, exocytosis of secretory granules and regulation of signal transmission. Function is isoform-specific. Alpha-type isoforms have a long N-terminus with six laminin G-like domains and play an important role in synaptic signal transmission. Alpha-type isoforms play a role in the regulation of calcium Channel activity and Ca(2+)-triggered neurotransmitter release at synapses and at neuromuscular junctions. They play an important role in Ca(2+)-triggered exocytosis of secretory granules in pituitary gland. They may effect their functions at synapses and in endocrine cells via their interactions with proteins from the exocytotic machinery. Likewise, alpha-type isoforms play a role in regulating the activity of postsynaptic NMDA receptors, a subtype of glutamate-gated ion Channels. Both alpha-type and beta-type isoforms may play a role in the formation or maintenance of synaptic junctions via their calcium-dependent interactions (via the extracellular domains) with neuroligin family members, CBLN1 or CBLN2. In vitro, triggers the de novo formation of presynaptic structures. May be involved in specification of excitatory synapses. Alpha-type isoforms were first identified as receptors for alpha-latrotoxin from spider venom (By similarity).

Research_area:Neuroscience

Applications:ELISA

Target_protein:NRXN1

Reactivity:Human

Assay type:Sandwich

Sensitivity:4.89ng/L

Detection range:10-4000ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Neurexin 1

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q9ULB1

MASS(Da):161,883

GeneID:9378

Synonyms:Neurexin I-alpha;Neurexin-1;Neurexin-1-alpha;NRXN 1;NRXN1

Gene names:NRXN1

Standard solution:4800ng/L