Human Myotonin-protein Kinase, DMPK ELISA Kit

SKU: E5723Hu

Size:96 Tests-1 Kit

Background:Non-receptor serine/threonine protein kinase which is necessary for the maintenance of skeletal muscle structure and function. May play a role in myocyte differentiation and survival by regulating the integrity of the nuclear envelope and the expression of muscle-specific genes. May also phosphorylate PPP1R12A and inhibit the myosin phosphatase activity to regulate myosin phosphorylation. Also critical to the modulation of cardiac contractility and to the maintenance of proper cardiac conduction activity probably through the regulation of cellular calcium homeostasis. Phosphorylates PLN, a regulator of calcium pumps and may regulate sarcoplasmic reticulum calcium uptake in myocytes. May also phosphorylate FXYD1/PLM which is able to induce chloride currents. May also play a role in synaptic plasticity.

Research_area:Signal Transduction

Applications:ELISA

Target_protein:DMPK

Reactivity:Human

Assay type:Sandwich

Sensitivity:9.16ng/L

Detection range:20-3500ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Myotonin-Protein Kinase

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q09013

MASS(Da):69,385

GeneID:1760

Synonyms:DM1 protein kinase;DMK;DM-kinase;DMPK;MT-PK;Myotonic dystrophy protein kinase;Myotonin-protein kinase

Gene names:DMPK

Standard solution:4000ng/L