Human Myosin Light Chain 3, MYL3 ELISA Kit

SKU: E6684Hu

Size:96 Tests-1 Kit

Background:Myosin essential light chain (ELC), ventricular/cardiac isoform is a protein that in humans is encoded by the MYL3 gene. This cardiac ventricular/slow skeletal ELC isoform is distinct from that expressed in fast skeletal muscle (MYL1) and cardiac atrial muscle (MYL4). Ventricular ELC is part of the myosin molecule and is important in modulating cardiac muscle contraction. Studies have provided evidence for ELC as modulator of myosin crossbridge kinetics. Treating cardiac myofibrils with the lysine-rich N-terminal peptide (amino acids 5-14) evoked a supramaximal increase in cardiac myofibrillar MgATPase activity at submaximal calcium concentrations, and further studies demonstrated that this region of ELC modulates the affinity of myosin for actin.

Research_area:Signal Transduction

Applications:ELISA

Target_protein:MYL3

Reactivity:Human

Assay type:Sandwich

Sensitivity:12.93ng/L

Detection range:20-4500ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Myosin Light Chain 3

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:P08590

MASS(Da):21,932

GeneID:4634

Synonyms:Cardiac myosin light chain 1;CMH8;CMLC1;MLC1SB;MLC1V;MLC-lV/sb;MYL3;Myosin light chain 1, slow-twitch muscle B/ventricular isoform;Myosin light chain 3;Ventricular myosin alkali light chain;Ventricular myosin light chain 1;Ventricular/slow twitch myosin alkali light chain;VLC1;VLCl

Gene names:MYL3

Standard solution:4800ng/L