Human Myogenin, MYOG ELISA Kit

SKU: E0421Hu

Size:96 Tests-1 Kit

Background:Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation, cell cycle exit and muscle atrophy. Essential for the development of functional embryonic skeletal fiber muscle differentiation. However is dispensable for postnatal skeletal muscle growth; phosphorylation by CAMK2G inhibits its transcriptional activity in respons to muscle activity. Required for the recruitment of the FACT complex to muscle-specific promoter regions, thus promoting gene expression initiation. During terminal myoblast differentiation, plays a role as a strong activator of transcription at loci with an open chromatin structure previously initiated by MYOD1. Together with MYF5 and MYOD1, co-occupies muscle-specific gene promoter core regions during myogenesis. Cooperates also with myocyte-specific enhancer factor MEF2D and BRG1-dependent recruitment of SWI/SNF chromatin-remodeling enzymes to alter chromatin structure at myogenic late gene promoters. Facilitates cell cycle exit during terminal muscle differentiation through the up-regulation of miR-20a expression, which in turn represses genes involved in cell cycle progression. Binds to the E-box containing (E1) promoter region of the miR-20a gene. Plays also a role in preventing reversal of muscle cell differentiation. Contributes to the atrophy-related gene expression in adult denervated muscles. Induces fibroblasts to differentiate into myoblasts (By similarity).

Research_area:Others

Applications:ELISA

Target_protein:MYOG

Reactivity:Human

Assay type:Sandwich

Sensitivity:8.02ng/L

Detection range:15-3000ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Myogenin

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:P15173

MASS(Da):25,037

GeneID:4656

Synonyms:bHLHc3;Class C basic helix-loop-helix protein 3;Myf-4;MYOG;Myogenic factor 4;Myogenin

Gene names:MYOG

Standard solution:3200ng/L