Human Myeloblastin ELISA Kit PicoKine®

SKU: EK2034

Size: 96 wells/kit, with removable strips.

Storage: Store at 4℃ for 6 months, at -20℃ for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Form:

Reactivity: Human

Applications: ELISA

Application Details:

Gene Name: PRTN3

Specificity: Natural and recombinant human Myeloblastin

Background: Proteinase 3 also known as PRTN3 is an enzyme that in humans is encoded by the PRTN3 gene. This gene is mapped to 19p13.3. PRTN3 is a serine protease enzyme expressed mainly in neutrophil granulocytes. Its exact role in the function of the neutrophil is unknown, but, in human neutrophils, proteinase 3 contributes to the proteolytic generation of antimicrobial peptides. It is also the target of anti-neutrophil cytoplasmic antibodies (ANCAs) of the c-ANCA (cytoplasmic subtype) class, a type of antibody frequently found in the disease granulomatosis with polyangiitis.

Immunogen: Expression system for standard: E.coli; Immunogen sequence: I28-R248

Clonality:

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Reconstitution:

Reference:

Uniprot ID: P24158

Host:

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Cross Reactivity: There is no detectable cross-reactivity with other relevant proteins.

Isotype:

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Observed Molecular Weight:

Calculated Molecular Weight:

Gene ID: 5657

Protein Name: Myeloblastin

Gene Full Name: proteinase 3

Synonyms: ACPA; AGP7; C ANCA; C ANCA antigen; Leukocyte proteinase 3; MBN; MBT; Myeloblastin; Neutrophil proteinase 4; P29; PR 3; PR3; proteinase 3; PRTN3; Wegener autoantigen