Human/Mouse COX-2 ELISA Kit PicoKine®

SKU: EK2289

Size: 96 wells/kit, with removable strips.

Storage: Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Form:

Reactivity: Human,Mouse

Applications: ELISA

Application Details:

Gene Name: PTGS2

Specificity:

Background: Cyclooxygenase-2 (COX-2), also known as Prostaglandin-endoperoxide synthase 2 (HUGO PTGS2), is an enzyme that in humans is encoded by the PTGS2 gene. PTGS2 (prostaglandin-endoperoxide synthase 2) is a gene that encodes an enzyme responsible for catalyzing the conversion of arachidonic acid into prostaglandins. Prostaglandins are lipid signaling molecules that play crucial roles in regulating inflammation, pain, and reproductive processes. PTGS2 is expressed in various tissues, particularly in sites of inflammation and certain tumor cells, where its expression levels are often significantly elevated. The activity of this gene is regulated by various stimuli, including cytokines, hormones, and growth factors, making it a key player in pathological conditions such as inflammation, cancer, and cardiovascular diseases. Due to its involvement in these diseases, PTGS2 has become a potential drug target, especially in the development of nonsteroidal anti-inflammatory drugs (NSAIDs).

Immunogen: Expression system for standard: NS0; Immunogen sequence: A18-L604

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Reference:

Uniprot ID: P35354

Host:

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Cross Reactivity: There is no detectable cross-reactivity with other relevant proteins.

Isotype:

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Gene ID: 5743

Protein Name: Prostaglandin G/H synthase 2

Gene Full Name: prostaglandin-endoperoxide synthase 2

Synonyms: COX 2; COX2; COX2/ Cyclooxygenase 2; COX2/ Cyclooxygenase 2/ PTGS2; Cyclooxygenase 2; GRIPGHS; hCox 2; PGG/HS; PGH synthase 2; PGHS 2; PHS 2; PHS II; Prostaglandin G/H synthase 2; Prostaglandin H2 synthase 2; PTGS2