Human Mothers Against Decapentaplegic Homolog 7, SMAD7 ELISA Kit

SKU: E0639Hu

Size:96 Tests-1 Kit

Background:Antagonist of signaling by TGF-beta (transforming growth factor) type 1 receptor superfamily members; has been shown to inhibit TGF-beta (Transforming growth factor) and activin signaling by associating with their receptors thus preventing SMAD2 access. Functions as an adapter to recruit SMURF2 to the TGF-beta receptor complex. Also acts by recruiting the PPP1R15A-PP1 complex to TGFBR1, which promotes its dephosphorylation. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator.

Research_area:Signal Transduction; Epigenetics and Nuclear Signaling

Applications:ELISA

Target_protein:SMAD7

Reactivity:Human

Assay type:Sandwich

Sensitivity:0.022ng/ml

Detection range:0.05-20ng/ml

Sample type:Serum, plasma or other biological fluids

Full product name:Mothers Against Decapentaplegic Homolog 7

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:O15105

MASS(Da):46,426

GeneID:4092

Synonyms:hSMAD7;MAD homolog 7;MAD homolog 8;Mothers against decapentaplegic homolog 7;Mothers against decapentaplegic homolog 8;Mothers against DPP homolog 7;Mothers against DPP homolog 8;SMAD 7;SMAD family member 7;SMAD7

Gene names:SMAD7

Standard solution:24ng/ml