Human Mothers Against Decapentaplegic Homolog 3, SMAD3 ELISA Kit

SKU: E2912Hu

Size:96 Tests-1 Kit

Background:Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD3/SMAD4 complex, activates transcription. Also can form a SMAD3/SMAD4/JUN/FOS complex at the AP-1/SMAD site to regulate TGF-beta-mediated transcription. Has an inhibitory effect on wound healing probably by modulating both growth and migration of primary keratinocytes and by altering the TGF-mediated chemotaxis of monocytes. This effect on wound healing appears to be hormone-sensitive. Regulator of chondrogenesis and osteogenesis and inhibits early healing of bone fractures. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator.

Research_area:Signal Transduction

Applications:ELISA

Target_protein:SMAD3

Reactivity:Human

Assay type:Sandwich

Sensitivity:0.047ng/ml

Detection range:0.1-35ng/ml

Sample type:Serum, plasma or other biological fluids

Full product name:Mothers Against Decapentaplegic Homolog 3

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:P84022

MASS(Da):48,081

GeneID:4088

Synonyms:hMAD-3;hSMAD3;JV15-2;MAD homolog 3;Mad3;Mothers against decapentaplegic homolog 3;Mothers against DPP homolog 3;SMAD 3;SMAD family member 3;SMAD3

Gene names:SMAD3

Standard solution:40ng/ml