Human Microtubule-associated Proteins 1A/1B Light Chain 3B, MAP1LC3B ELISA Kit

SKU: E4774Hu

Size:96 Tests-1 Kit

Background:Ubiquitin-like modifier involved in formation of autophagosomal vacuoles (autophagosomes). Plays a role in mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production (PubMed: 28017329). While LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation. Promotes primary ciliogenesis by removing OFD1 from centriolar satellites via the autophagic pathway. Through its interaction with the reticulophagy receptor TEX264, participates in the remodeling of subdomains of the endoplasmic reticulum into autophagosomes upon nutrient stress, which then fuse with lysosomes for endoplasmic reticulum turnover (PubMed: 31006538, PubMed: 31006537).

Research_area:Cancer

Applications:ELISA

Target_protein:MAP1LC3B

Reactivity:Human

Assay type:Sandwich

Sensitivity:5.28ng/L

Detection range:10-2000ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Microtubule-Associated Proteins 1A/1B Light Chain 3B

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q9GZQ8

MASS(Da):14,688

GeneID:81631

Synonyms:Autophagy-related protein LC3 B;Autophagy-related ubiquitin-like modifier LC3 B;MAP1 light chain 3-like protein 2;MAP1A/MAP1B LC3 B;MAP1A/MAP1B light chain 3 B;MAP1LC3B;Microtubule-associated protein 1 light chain 3 beta;Microtubule-associated proteins 1A/1B light chain 3B

Gene names:MAP1LC3B

Standard solution:2400ng/L