Human Matrix Metalloproteinase 14, MMP14 ELISA Kit

SKU: E0714Hu

Size:96 Tests-1 Kit

Background:Endopeptidase that degrades various components of the extracellular matrix such as collagen. Activates progelatinase A. Essential for pericellular collagenolysis and modeling of skeletal and extraskeletal connective tissues during development (By similarity). May be involved in actin cytoskeleton reorganization by cleaving PTK7 (PubMed: 20837484). Acts as a positive regulator of cell growth and migration via activation of MMP15. Involved in the formation of the fibrovascular tissues in association with pro-MMP2 (PubMed: 12714657). Cleaves ADGRB1 to release vasculostatin-40 which inhibits angiogenesis (PubMed: 22330140).

Research_area:Cardiovascular; Signal Transduction; Cancer; Cell Biology

Applications:ELISA

Target_protein:MMP14

Reactivity:Human

Assay type:Sandwich

Sensitivity:0.62ng/ml

Detection range:1-400ng/ml

Sample type:Serum, plasma or other biological fluids

Full product name:Matrix Metalloproteinase 14

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:P50281

MASS(Da):65,894

GeneID:4323

Synonyms:Matrix Metalloproteinase-14;Membrane-type Matrix Metalloproteinase 1;Membrane-type-1 Matrix Metalloproteinase;MMP 14;MMP14;MMP-14;MMP-X1;MT1MMP;MT1-MMP;MT-MMP 1;MTMMP1

Gene names:MMP14

Standard solution:480ng/ml