Human Low Density Lipoprotein Receptor Related Protein 8, LRP8 ELISA Kit

SKU: E2296Hu

Size:96 Tests-1 Kit

Background:Cell surface receptor for Reelin (RELN) and apolipoprotein E (apoE)-containing ligands. LRP8 participates in transmitting the extracellular Reelin signal to intracellular signaling processes, by binding to DAB1 on its cytoplasmic tail. Reelin acts via both the VLDL receptor (VLDLR) and LRP8 to regulate DAB1 tyrosine phosphorylation and microtubule function in neurons. LRP8 has higher affinity for Reelin than VLDLR. LRP8 is thus a key component of the Reelin pathway which governs neuronal layering of the forebrain during embryonic brain development. Binds the endoplasmic reticulum resident receptor-associated protein (RAP). Binds dimers of beta 2-glycoprotein I and may be involved in the suppression of platelet aggregation in the vasculature. Highly expressed in the initial segment of the epididymis, where it affects the functional expression of clusterin and phospholipid hydroperoxide glutathione peroxidase (PHGPx), two proteins required for sperm maturation. May also function as an endocytic receptor. Not required for endocytic uptake of SEPP1 in the kidney which is mediated by LRP2 (By similarity). Together with its ligand, apolipoprotein E (apoE), may indirectly play a role in the suppression of the innate immune response by controlling the survival of myeloid-derived suppressor cells (By similarity).

Research_area:Neuroscience

Applications:ELISA

Target_protein:LRP8

Reactivity:Human

Assay type:Sandwich

Sensitivity:5.14ng/L

Detection range:10-4000ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Low Density Lipoprotein Receptor Related Protein 8

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q14114

MASS(Da):105,634

GeneID:7804

Synonyms:Apolipoprotein E receptor 2;Low-density lipoprotein receptor-related protein 8;LRP 8;LRP8;LRP-8

Gene names:LRP8

Standard solution:4800ng/L