Human Langerin/CD207 ELISA Kit PicoKine®

SKU: EK2162

Size: 96 wells/kit, with removable strips.

Storage: Store at 4℃ for 6 months, at -20℃ for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Form:

Reactivity: Human

Applications: ELISA

Application Details:

Gene Name: CD207

Specificity: Natural and recombinant human CD207

Background: Langerin (CD207) is a type II transmembrane protein which is encoded by the CD207 gene in humans. The protein encoded by this gene is expressed only in Langerhans cells which are immature dendritic cells of the epidermis and mucosa. It is localized in the Birbeck granules, organelles present in the cytoplasm of Langerhans cells and consisting of superimposed and zippered membranes. It is a C-type lectin with mannose binding specificity, and it has been proposed that mannose binding by this protein leads to internalization of antigen into Birbeck granules and providing access to a nonclassical antigen-processing pathway. Mutations in this gene result in Birbeck granules deficiency or loss of sugar binding activity.

Immunogen: Expression system for standard: NS0; Immunogen sequence: P65-P328

Clonality:

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Reconstitution:

Reference:

Uniprot ID: Q9UJ71

Host:

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Conjugate:

Cross Reactivity: There is no detectable cross-reactivity with other relevant proteins.

Isotype:

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Clone Number:

Observed Molecular Weight:

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Gene ID: 50489

Protein Name: C-type lectin domain family 4 member K

Gene Full Name: CD207 molecule

Synonyms: CD207; CD207 molecule; langerin; CLEC4K; Langerin