Human Kallikrein-6 / KLK6 ELISA Kit PicoKine®

SKU: EK0818

Size: 96 wells/kit, with removable strips.

Storage: Store at 4℃ for 6 months, at -20℃ for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Form:

Reactivity: Human

Applications: ELISA

Application Details:

Gene Name: KLK6

Specificity: Natural and recombinant human Kallikrein-6

Background: KLK6 (Kallikrein-related peptidase 6), also called KALLIKREIN 6, NEUROSIN, PROTEASE M, ZYME or PRSS9, is a protein that in humans is encoded by the KLK6 gene. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. The encoded enzyme is regulated by steroid hormones. Northern blot analysis revealed that the PRSS9 mRNA was expressed in several primary tumors and cell lines from mammary, prostate, and ovarian cancers, but was not detected in any metastases of these cancers. The KLK6 gene is mapped on 19q13.41. In tissue culture, the enzyme has been found to generate amyloidogenic fragments from the amyloid precursor protein, suggesting a potential for involvement in Alzheimer's disease. Upon cellular stress, neurosin was released from mitochondria to the cytosol, which resulted in the increase of degraded alpha-synuclein species. Neurosin may play a significant role in physiologic alpha-synuclein degradation and also in the pathogenesis of synucleinopathies.

Immunogen: Expression system for standard: NS0; Immunogen sequence: L22-K244

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Uniprot ID: Q92876

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Cross Reactivity: There is no detectable cross-reactivity with other relevant proteins.

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Gene ID: 5653

Protein Name: Kallikrein-6

Gene Full Name: kallikrein related peptidase 6

Synonyms: kallikrein related peptidase 6; Bssp; Klk7; PRSS18; PRSS9; SP59; hK6; KLK6