Human Interleukin 36 Beta, IL-36B ELISA Kit

SKU: E4463Hu

Size:96 Tests-1 Kit

Background:Cytokine that binds to and signals through the IL1RL2/IL-36R receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells linked to a pro-inflammatory response. Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coreceptor IL1RAP. Stimulates production of interleukin-6 and interleukin-8 in synovial fibrobasts, articular chondrocytes and mature adipocytes. Induces expression of a number of antimicrobial Peptides including beta-defensins 4 and 103 as well as a number of matrix metalloproteases. Seems to be involved in skin inflammatory response by acting on keratinocytes, dendritic cells and indirectly on T-cells to drive tissue infiltration, cell maturation and cell proliferation. In cultured keratinocytes induces the expression of macrophage, T-cell, and neutrophil chemokines, such as CCL3, CCL4, CCL5, CCL2, CCL17, CCL22, CL20, CCL5, CCL2, CCL17, CCL22, CXCL8, CCL20 and CXCL1, and the production of proinflammatory cytokines such as TNF-alpha, IL-8 and IL-6.

Research_area:Immunology

Applications:ELISA

Target_protein:IL36B

Reactivity:Human

Assay type:Sandwich

Sensitivity:0.24ng/L

Detection range:0.5-150ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Interleukin 36 Beta

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q9NZH7

MASS(Da):18,522

GeneID:27177

Synonyms:FIL1 eta;IL 36B;IL-1 eta;IL-1F8;IL-1H2;IL36B;Interleukin-1 eta;Interleukin-1 family member 8;Interleukin-1 homolog 2;Interleukin-36 beta

Gene names:IL36B

Standard solution:160ng/L